** 0.01; *** 0.005. increase in liver size and the development of liver tumor15,16,17. Deregulation of Hpo pathway leads to the stabilization and nuclear sequestration of YAP. Nuclear YAP binds to and activates the transcription factors TEADs (the TEAD/TEF family transcription factors) and eventually turns on the expression of downstream genes including and reduced cell […]
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